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Additionally, the oxidation status of peroxiredoxin 1 (PRDX1), a direct substrate of TRX, was tested by employing a redox western blot to reflect the activity of TXNRD1 indirectly

AHK-Cu has several effects: it increases the number of fibroblasts (cells that help to keep skin elastic) and boosts VEGF (a substance that encourages new blood vessel formation in the scalp), enhances SOD (a substance that neutralises free radicals that trigger DHT production) and reduces TGF-beta 1 secretion by fibroblasts, making it a key pathway in countering DHT-related hair thinning

Notably, the incidence of skin rashes is comparable to that observed with allopurinol