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The authors suggested that the higher incidence of inclusions in liver might be related to slowing of the tumor growth leading to lower incidence of hepatocellular tumors in C57BL/6 mice

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doi: 10.3390/nu13072228

This framing also explains why GLP-1s may be most effective early in the disease continuum, or as part of preventive strategies aimed at preserving cerebral blood flow, metabolic health, and mitochondrial resilience before irreversible neurodegeneration takes hold [14,15]