A federal MDL has been created for people diagnosed with NAION after taking Ozempic or another GLP-1 drug
When coming off a GLP-1, watch for increased hunger and food noise persistent, intrusive thoughts about food as well as a diminished ability to feel full with smaller portions
However, the well-recognized pleotropic effects of GLP-1R agonists (normalization of neurogenesis and synaptic plasticity, protection against neuronal apoptosis, and suppression of increased oxidative stress), in conjunction with the presence of GLP-1Rs in the hypothalamic nuclei that regulate sleep and wakefulness, suggest several possible direct effects of GLP-1R agonists in affecting sleepiness and other related parameters (memory, anxiety, and depression) [77, 114]
They lose lean muscle mass and regain the weight, risking conditions like sarcopenic obesity, leaving them potentially worse off than before they started the medication