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MCH1R antagonists have also been shown to be efficacious in animal models of depressive behavior although the precise mechanism for the antidepressant effects are not yet clearly defined

These side effects are usually experienced in the beginning stages of the treatment and subside as your body becomes used to the medication

Patients taking SGLT2 inhibitors alongside tirzepatide should be particularly vigilant for signs of euglycaemic diabetic ketoacidosis, which can occur even when blood glucose levels are not markedly elevated

About 40% of patients with recurrent migraines had lower TAC levels (Gross et al., 2021)