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One placebo-controlled trial, called ATTAIN-MAINTAIN, followed adults who had previously completed the SURMOUNT-5 obesity trial, a randomized controlled study evaluating whether tirzepatide, the active ingredient in Zepbound, led to greater body weight reduction versus semaglutide in adults with obesity

The risk of using degraded peptide, reduced effectiveness, unpredictable dosing, potential contamination, always outweighs the cost of a replacement vial

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