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In another study, mental health diagnoses were prevalent among cirrhosis patients and significantly increased the risk of all-cause mortality: 54% for any mental health diagnosis, 11% for non-alcohol-use disorder (AUD)/substance-use disorder (SUD), and 44% for AUD/SUD

As a specific example of a therapy contemplated by embodiments of the invention, the HGF mimics may be used for the treatment of dementia

In the SURMOUNT-1 study, a phase 3 clinical trial in obese patients, randomized participants in a 1:1:1:1 ratio to tirzepatide (5, 10, 15 mg) or placebo over 72 weeks, significant weight reductions were observed at 72 weeks: 15.0% for 5 mg, 19.5% for 10 mg, 20.9% for 15 mg, compared to 3.1% for placebo [18]

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