Obesity is a chronic, multifactorial disease characterized by excessive fat accumulation that poses significant health risks
Clinically, I think of these medications as potentially powerful adjuncts but not replacements for therapy, behavioral change, or deeper work around coping and meaning, he said
1,2 These activities are constantly challenged by intrinsic and extrinsic perturbations, including increased protein synthesis, ER-Ca 2+ depletion, dysregulated redox homeostasis, energy deprivation, hypoglycemia, hypoxia, and inflammatory stimuli, resulting in improper protein conformation and misfolding, often referred to as nonnative or aberrant conformation
2.2 Dosing instructions / Titration Typical titration (dosing adjustment) starts very low and increases over weeks up to 15 mg phentermine / 92 mg topiramate daily based on tolerance