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819,820 conformational switching by one or more G-domain switches upon GTP hydrolysis is likely the key structural trigger that orchestrates NMC function in a metallochaperone cycle (Figure 35B)

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This inhibition causes AICAR to accumulate intracellularly

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Frontiers in Neuroscience, 14, 1062

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no large-scale controlled human clinical trials establishing safety or efficacy currently exist

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