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It may help reduce inflammation by inhibiting the production of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6)

They are no longer used as a first add-on in most NICE pathways but still have a role when cost or specific tolerability concerns make newer drugs unsuitable

Evidence of lipid dysregulation and energy issues was also observed in plasma, with elevated odd-chain acylcarnitines in GW agent-exposed mice, and in veterans with GWI, relative to their respective controls

This could involve temporarily reducing the dose, switching to a different GLP-1 receptor agonist with a different pharmacokinetic profile, or investigating whether concurrent medications contribute to tiredness