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Endothelium-dependent vasodilation is impaired in individuals with elevated serum cholesterol concentrations, as well as in patients with coronary heart disease or diabetes mellitus

The "safer" option depends on which specific side effects are most concerning to you and your individual risk factors

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The PCR product containing the polymorphism rs2070593 was digested with 7 U of Psp CI restriction enzyme (Sibenzyme, Novosibirsk, Russia) producing two fragments of 183 and 180 bp (these bands overlap each other at electrophoresis) in case of the G allele and leaving the A allele uncut (one fragment of 363 bp) on 2%-agarose gel