The molecule is classified as a triple receptor agonist because it interacts with three endocrine receptors involved in metabolic regulation: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)
Studies have found that under pathological conditions, astrocytes are activated by A to produce cytoinflammatory factors, complement, oxygen free radicals, etc., which then trigger inflammation, promote nerve cell damage and death, and ultimately aggravate Alzheimers disease (Do et al., 2014
Cholesterol-induced non-alcoholic fatty liver disease and atherosclerosis aggravated by systemic inflammation
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