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7 Excess fat can build up in the liver, which, over time, can lead to inflammation and severe scarring of the liver

Nausea, vomiting, flatulence (gas), and indigestion also occur in many patients

When the N -protecting group was replaced by other aliphatic amides such as cyclopropanecarbonyl and propionyl groups, the reactions proceeded smoothly to afford desired products 5e and 5f in 45 and 80% yield, respectively

Effect via the GIP receptor At the same time, inhibition of the GLP-1 receptor had only a minor effect on insulin secretion induced by the new drug, which further confirms that signaling through the GIP receptor plays a crucial role in the novel drug mechanism of action, while the "mediating" role of the GLP-1 receptor is less important