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Additionally, in the trial examining alcohol use disorder, a significant reduction in alcohol consumption was observed only in a specific subgroup of patients with obesity, suggesting that patient characteristics, such as BMI, might influence treatment outcomes

In multiple rodent models of chronic stress (a shared risk factor for major psychiatric illnesses), administration of LAC leads to a rapid and persistent antidepressant-like response by increasing histone acetylation and expression of key genes, including mGlu2 receptors and the downstream brain-derived neurotrophic factor BDNF [27, 30, 34,35,36,37]

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