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These symptoms may indicate peripheral vascular issues, particularly relevant for patients with diabetes who have increased cardiovascular risk

This activation involves phosphorylation and nuclear accumulation of TAp63 in oocytes, which subsequently triggers the expression of pro-apoptotic Bcl-2 family members, including PUMA, NOXA, and Bax, initiating the apoptotic pathway (Suh et al., 2006

(2017) 18:E1649