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These cumulative insults lead to epidermal thinning, degradation of collagen and elastin, and impairment of the skin barrier, which manifest clinically as wrinkles, delayed wound healing, and increasing vulnerability to dermatoses

Discussion This study demonstrates a significant association between elevated levels of the HPA axis hormones (cortisol and DHEA-S) and markers of oxidative stress in a large sample of Korean adults, independent of age and BMI