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2.4 Metabolic and mitochondrial dysfunction in diabetes An animal experiment using db/db mice, a model of type 2 diabetes, demonstrated that disturbances in circulatory metabolism and brain energy metabolism, particularly mitochondrial dysfunction, may contribute to cognitive impairment

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A detailed metabolic scheme of -tocopherol in the various cellular departments, endoplasmic reticulum, peroxisomes, and mitochondrion, is depicted in Figure 3