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Kramer CK, Zinman B, Choi H, Retnakaran R (2016) Predictors of sustained drug-free diabetes remission over 48 weeks following short-term intensive insulin therapy in early type 2 diabetes

Understand the dosing schedules and titration protocols so you can discuss them intelligently

The landscape is also shaped by manufacturing capacity concerns: At last weeks Semafor World Economy, Eli Lillys CEO framed new oral pills as a huge scale solution for global supply constraints, saying that no matter how hard we want to try, we cannot reach the planet with traditional injectable treatments.

The Randle cycle essentially describes that when fatty acid oxidation is active there is a significant reduction in the uptake and utilization of glucose by inhibition of PDH flux, but it also works the other way around, so the production of acetyl-CoA from glycolysis will inhibit fatty acid oxidation through the generation of malonyl-CoA which can inhibit CPT I [99]