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Head-to-head trials of treatment combinations: More head-to-head trials comparing different drug combinations would help establish optimal treatment algorithms in PCOS, which is characterized by a multi-system abnormality affecting multiple systems

About the GLP-1 RAs effects, it has been described that Exendin-4 attenuates NF-B p65 expression in the EAE spinal cord and blocks IB degradation in LPS-stimulated primary microglia, additionally demonstrating that exendin-4 can stop microglial polarization (Lee et al., 2018

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PMID: 40010930, DOI: 10.1016/j.jacc.2025.01.016