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Once inserted into the rectum, the suppository comes into contact with body heat, causing it to dissolve or melt

5 Mechanistically, exercise-induced interleukin-6 (IL-6) appears to stimulate GLP-1 secretion from intestinal L-cells and pancreatic -cells in experimental models, which may contribute to improved appetite regulation and insulin secretion during and after exercise

25 that found reductions in body weight and adiposity in mice treated with -galactosyl ceramide (-GalCer) that presented enrichment in iNKTs in WAT, an effect abolished by depleting this immune population

The safest takeaway is a better checklist for clinician review, not a do-it-yourself medical decision