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Apoptosis/necroptosis inhibitors Pan-caspase inhibitors Z-VAD-FMK block caspase-3/9, while RIPK3 inhibitors suppress necroptosis, reducing hepatocyte loss in animal models [40, 45]

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Further, from national and international dietary survey data across the globe, sugar, saturated fat and sodium intakes remain above recommended levels

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Overall, GLP-1 RAs demonstrate promising clinical benefits across multiple domains, while further large-scale and high-quality studies are warranted to confirm these findings and elucidate the underlying mechanisms

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