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Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism

Future research should incorporate female animal models to investigate potential sex-specific responses to MAOB inhibition, which will be essential for fully understanding the translational implications of astrocytic GABA dysregulation in PTSD across sexes

Under pathological conditions, long-term excessive stress can cause damage to the endoplasmic reticulum function, and endoplasmic reticulum stress activates the apoptosis pathway, which leads to nerve cell damage and even death (Xuan et al., 2020)

It stimulates collagen synthesis and the production of glycosaminoglycans (GAGs), the structural components of connective tissue, cartilage, and the extracellular matrix