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doi: 10.1111/pim.12401 125 O'BrienBAHuangYGengXDutzJPFinegoodDT

Furthermore, polyphenols have demonstrated their therapeutic potential through the regulation of key signaling pathways such as Akt, Nrf2, STAT, and MAPK, which play critical roles in neuroprotection and the bodys immune response

Moreover, these results of the multi-lineage differentiation capacity were validated by the upregulation of the FABP4 known as intracellular lipid chaperones, which regulate lipid trafficking and responses in cells [39,40], as well as PPAR critically involved in the regulation of a large number of genes, which regulate energy homeostasis, glucose triglyceride and lipoprotein metabolism, de novo lipogenesis, fatty acid uptake, oxidation, storage and export, cell proliferation, inflammation, and vascular tissue function [41]