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The peptide is structurally derived from native human GLP-1(7-37) with two amino acid substitutions (Aib at position 8 for DPP-IV resistance, Arg substitution at position 34) and a C18 fatty diacid moiety conjugated via a Glu-(AEEA) linker enabling reversible albumin binding and an extended pharmacokinetic profile compatible with once-weekly dosing
Variations in the GLP1R gene (such as rs6923761) influence how efficiently your cells receive GLP-1 signals, which can affect both weight loss outcomes and digestive tolerance
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The rate of weight loss may vary depending on individual factors and the duration of treatment
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