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Author contributions LP and RL conceived the ideas, designed the experiments, collected the data and wrote the manuscript

While supplements are absorbed through the digestive system and work systemically, creams are designed for targeted use

A reticulocyte count may rise after about one week of treatment, with full blood count typically normalising within 8 weeks

Up to now, the choice of the specific treatment can be based on a lactylation scoring model, which reflected the intercellular activation and communication of immune cells within the TME, providing a new approach for assessing the disease status of glioma patients and guiding treatment strategies [173]