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Practical Application 12-14 hour overnight fast: Eat between 8am-6pm or 9am-7pm First meal should be protein-rich: Maximizes L-cell response after fasting Last meal 2-3 hours before bed: Supports overnight metabolic processes Maintain consistency: L-cells adapt to regular feeding patterns Important: Time-restricted eating isnt appropriate for everyone

More importantly for weight loss, GLP-1 slows down digestion and sends fullness signals to the brain , reducing appetite