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For more than two decades, researchers pursued the goal of delivering GLP-1 receptor activation through an oral tablet, a pursuit complicated by the fundamental biochemistry of peptide drugs: their vulnerability to acid hydrolysis in the stomach, enzymatic degradation in the gastrointestinal tract, and poor absorption across the intestinal epithelium

Extensive research over the past decade has provided evidence that GLP-1 receptor agonists do not appear to increase the risk of pancreatic cancer

The freeze-thaw cycle is particularly destructive, far worse than simply storing at suboptimal warm temperatures