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Based on the previously elucidated of sitagliptin-derived DPP-4 inhibitors, the DPP-4 binding site consists of two primary pockets, S 1 and S 2 , and a subpocket known as the S 2 -extensive or S3 pocket (81) (Figure 2A)

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A 2021 study in JAMA Internal Medicine found that menopausal transition was independently associated with a 1.2 kg per year increase in visceral fat, even after controlling for age and physical activity