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Studies of the von Willebrand factor and fibrinogen (important vascular determinants of increased platelet aggregation and secretion that may be involved in the development of thrombosis) also favor the theory of platelet hyperactivity

87 Hematopoietic stem cells (HSCs) are located at the apex of the hematopoietic hierarchy and exhibit a distinct self-renewal and differentiation capacity

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Lifestyle factors such as smoking, excessive alcohol consumption, poor diet, and obesity are also major contributors to oxidative stress ( In conclusion, ROS play a dual role in sperm function, being essential for processes such as capacitation, motility, and fertilization at physiological levels, but harmful when produced in excess