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Therefore, increased iron uptake and decreased iron output can lead to iron overload and thus ferroptosis

PGRMC1 dimerization is required for binding to EGFR Because PGRMC1 is known to interact with EGFR and to accelerate tumour progression 18 , we examined the effect of haem-dependent dimerization of PGRMC1 on its interaction with EGFR by using purified proteins

Valent P, Akin C, Hartmann K, Reiter A, Gotlib J, Sotlar K, et al

Conclusion The form of lipid peroxidation with the result of molecular oxygen conversion to ROS with various environmental factors particularly smoking cigarette, alcohol, UV rays, and other oxidants leads to oxidative stress