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However, mAb treatment tended to oppose age-related changes in 30 of these metabolites (22 marginally significant after FDR correction), including a reduction in the age-related rise of many glycerophospholipids, and a distinct clustering of metabolites from heart tissue in Old Con versus Old mAb-treated animals by PCA (Supplementary Fig

Surprisingly, despite the broad systemic anti-inflammatory actions of GLP-1RAs, much (1001000 fold) lower levels of GLP-1R mRNA transcripts are detected in spleen, thymus, lymph nodes and hematopoietic cell lineages, relative to levels of GLP-1R expression in gut IELs [138, 139], suggesting that a substantial proportion of GLP-1 action on immune cells may be indirect

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doi: 10.2337/db14-1577 38 WongCKYustaBKoehlerJABaggioLLMcLeanBAMatthewsDet al