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Canada has seen significant growth in hormone optimization clinics over the past decade, with major cities like Toronto, Vancouver, Calgary, and Montreal all having multiple options for men seeking supervised testosterone therapy combined with comprehensive blood work monitoring

The most frequently reported side effects in Phase 2 trials are gastrointestinal: nausea, vomiting, diarrhoea, and constipation, typically dose-dependent and mild to moderate

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Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participants