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Approximately 25% of children who undergo Nissen Fundoplication experience post-prandial hypoglycemia ( Children with post-prandial hypoglycemia after Nissen fundoplication exhibit higher GLP-1 and insulin plasma concentrations, and lower plasma glucose nadir in response to an oral glucose tolerance test than controls

First, almost every included study did not consider thyroid events as the main result, only regarded them as safety results and did not monitor the changes in thyroid function at the same time

In the first study, the authors did not find any significant difference in biochemical hyperandrogenism in both intra and inter-groups, despite the significant improvement in anthropometric parameters in the group treated with liraglutide [57]