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Leveque et al., 2023

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Common Side Effects (Both Peptides) Mild injection site reactions (redness, itching, soreness) Temporary flushing or warmth after injection Occasional headaches, particularly in the first 1-2 weeks Mild water retention Increased appetite Side Effects More Common with CJC-1295 Due to its greater GH stimulation, CJC-1295 may carry slightly higher risk of: Joint stiffness or discomfort (from elevated GH/IGF-1) Tingling or numbness in extremities (paresthesia) More pronounced water retention Occasional dizziness Side Effects More Common with CJC-1295 with DAC The sustained GH elevation from the DAC form may increase the likelihood of: Prolonged water retention Blood sugar fluctuations (GH can reduce insulin sensitivity) Carpal tunnel-like symptoms Potential disruption of normal GH pulsatility When to Seek Medical Attention Contact your provider if you experience persistent joint pain, significant swelling, numbness that does not resolve, changes in blood sugar, or any symptom that interferes with daily activities

Furthermore, disrupted circadian rhythms are linked to higher risk for stroke and play a role in stroke outcome