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this includes chlorambucil (adduct formation through nucleophilic substitution of the atom of chlorine [118]), cyclophosphamide (acrolein is one its main metabolites conjugating to GSH and becoming significantly less cytotoxic than the parent compound [119]), mitomycin C (forming mono- and bis-conjugates with GSH to be detoxified [120]), and various tyrosine kinases inhibitors (such as axitinib and sunitinib [121])

This method may prove useful for understanding the physiological and pathological conditions under which overoxidized, DHA-containing forms of GPx-1 may accumulate in cells other than RBC

& Tomar, S

2010, Nov, 30;75(22):201720