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Overview of the tryptophan-kynurenine metabolic pathway The figure shows the tryptophan-kynurenine metabolic pathway, highlighting the vitamin B 6 -dependent enzymes

Cagrilintide is engineered to extend that biology into a once-weekly molecule with amylin and calcitonin receptor activity

It is used mainly as add-on to metformin when metformin alone is insufficient for glycemic control, particularly when there is a desire to minimize the risk for hypoglycemia