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It is commonly discussed in scientific literature related to energy balance, cellular metabolism, and its role in controlling and fine-tuning biological processes

People with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) should not use semaglutide or tirzepatide, based on animal study data

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Additionally, some research suggests chronic GLP-1 agonist use may reduce gastric acid secretion over time, though this finding remains controversial