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This timing leverages physiologic factors including reduced somatostatin inhibition during sleep, increased GHRH receptor sensitivity during evening hours, and optimal metabolic conditions supporting growth hormone synthesis and secretion, while morning or midday administration stimulates smaller daytime pulses with less consistent metabolic benefits

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Researchers in the Transregional Collaborative Research Center (SFB/TRR 219) Mechanisms of Cardiovascular Complications in Chronic Kidney Disease, led by Professor Joachim Jankowski of the RWTH Institute for Molecular Cardiovascular Research (IMCAR), are investigating the biological processes that connect kidney disease and cardiovascular disorders