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Moreno-Torres et al., 2022a

This 68-week study followed 1,961 adults with obesity or overweight who did not have diabetes

Substantial evidence indicates that the DPP-4-generated GLP-1 metabolites (GLP-1 (9-36amide) and GLP-1 (937)) have no major role in regulating glucose metabolism [[195], [196], [197]]

It happens due to its water retention property, as creatine can reduce water availability in the body, Hence, it is advisable to consume sufficient amounts of water and foods high in water content to avoid dehydration