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GSH prevents protein oxidation through S-glutathionylation mechanisms

Cross-sectional studies have shown that plasma and tissue glutathione concentrations decrease by approximately 10-15% per decade after age 45, and this decline is accelerated in conditions associated with chronic oxidative stress, including type 2 diabetes, cardiovascular disease, neurodegenerative diseases, HIV/AIDS, chronic liver disease, and chronic obstructive pulmonary disease (COPD) [2][3][10][11]

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We need antioxidants to fight off these free radicals, supporting circulation, when the peripheral arteries become clogged by plaque, they become narrow