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Besides, The mechanisms regulating GPX4 expression are ill-defined 53

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Hepatic fibrosis stage is the main predictor of liver-related morbidity and mortality: each unit increase in fibrosis stage confers a 2-fold increase in liver-related mortality and an approximately 1.5-fold increase in overall mortality [14]

It is worth noting that since SPNs project outside the blood-spinal cord barrier 61 , systemically injected GLP-1R agonists may easily access GLP-1Rs on the axon terminals of these cells in the sympathetic ganglia