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The animal research on tendons and gut tissue is probably the most consistent

Cell 178 , 275289 (2019)

Seventy percent of our immunity cells are either in the gut environment or in the vicinity, but if there is a disturbance in the gut barrier or an imbalance of bacteria that is, more bad than good the immune response will not be regular and a localized reaction can become systemic

Researchers designing combination protocols typically run controls with each compound in isolation alongside the combination arms to distinguish additive from synergistic effects and to identify which compound is driving each observed outcome