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The current work is predicated on previous suggestions that GLP-1 activity depends on adoption of a reverse turn near the peptide N-terminus, which raises the possibility that the N-terminal helical conformation in the cryo-EM structure of receptor-bound GLP-1 12 may not fully capture structural requirements for signaling

For pure weight-loss endpoints, retatrutide outperforms semaglutide by roughly 9 percentage points at peak dose: 24.2% versus ~15% mean body-weight loss at comparable durations [3][4]

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