Here's what you should know going in: Commonly reported effects include nausea, vomiting, diarrhea, and constipation, particularly during initial dose escalation Warnings and precautions in the prescribing information for applicable semaglutide and tirzepatide products cover pancreatitis, gallbladder disease, and kidney injury associated with volume depletion If you're on insulin or sulfonylureas, discuss hypoglycemia risk with your prescriber - GLP-1 medications can affect blood sugar control when combined with those drugs These medications slow gastric emptying, which can affect how orally taken medications are absorbed - worth flagging if you take other oral drugs regularly Certain FDA-approved semaglutide and tirzepatide products carry a boxed warning concerning thyroid C-cell tumors observed in rodents
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Blocking TG2, for instance, would stop the conversion of gluten to its modified form and prevent the inflammatory immune reaction from taking place
Because of the unknown potential for serious adverse reactions in the breastfed infant due to the possible accumulation of SNAC, an absorption enhancer for Wegovy tablets, and because there are alternative formulations of semaglutide that do not contain SNAC that can be used during lactation, advise patients that breastfeeding is not recommended during treatment with Wegovy tablets
