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For exposure controls, SGLT2is were selected as the positive control, based on evidence from previous cohort studies demonstrating their cardiovascular and kidney benefits in KTRs with DM [44]
This action suggests that GIP may play a role in adipose tissue fat storage
All together, these support the hypothesis of -cell exhaustion at the end road of insulin resistance, consistent with the pathological mechanisms underlying T2D ( In contrast to GLP-1 postprandial levels, which have been consistently reported to increase after RYGB, reports regarding the circulating levels of GIP following MBS are fewer and results have been inconsistent ( The discrepancies in the results across studies regarding the relation between postprandial GIP and GLP-1 levels and WR may be attributed to differences in the criteria used to define suboptimal outcomes, as well as the inclusion of patients with T2D in some analyses
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