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Dong H, Luo L, Zou M, Huang C, Wan X, Hu Y, Le Y, Zhao H, Li W, Zou F, Cai S (2017) Blockade of extracellular heat shock protein 90 by 1G6-D7 attenuates pulmonary fibrosis through inhibiting ERK signaling

788 In addition, discoveries such as the Cu-only SODs from an opportunistic fungal pathogen that dispose of the requirement for Zn altogether within a canonical Cu/Zn-dependent SOD fold, and which are strongly induced under conditions of Fe-starvation, highlights a potential of still uncovered regulatory and structural diversity within the superoxide dismutases

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Autorizzazioni e endpoint Approvazione accelerata / autorizzazione condizionata : percorsi regolatori che consentono a FDA ed EMA di rendere disponibile un farmaco per una malattia grave sulla base di un surrogate endpoint (come il miglioramento istologico), quando il beneficio dellimmediata disponibilit supera lincertezza residua