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CMvTC is characterized by aberrant nuclear and cytoplasmic expression of - catenin ( -catenin immunostaining is strong in cytoplasm and nuclei in the morular and cribriform areas, and it is only expressed in cell membrane of the non-tumoral follicular cells) (Figure 6)

However, a comprehensive review published in 2025 emphasized that the majority of this evidence remains preclinical , meaning it was not conducted in large, well-controlled human trials

In people with obesity and established cardiovascular disease but without diabetes, semaglutide 2.4 mg resulted in 20% reduction in major adverse cardiovascular events [(MACE), death from cardiovascular causes, nonfatal myocardial infarction or nonfatal stroke] compared to placebo (SELECT trial) after a mean follow-up of 39.8 months this is the first trial demonstrating cardiovascular benefit for an obesity pharmacotherapy [110]

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