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When Bloating is Most Common (The Titration Phase) Stomach pressure from gas, like most gastrointestinal side effects of semaglutide, tends to be worse at the beginning of treatment and when increasing your dose (also known as the titration phase)

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A phase 2 study (MARIPOSA randomized trial) demonstrated that, in patients with OSA, administration of aroxybutynin (an antimuscarinic agent) combined with atomoxetine (a norepinephrine reuptake inhibitor) led to modest but significant reductions in AHI (AHI reduction of 5.9 events/hour greater than placebo) over a 4-week period, though the use of atomoxetine was also associated with a reduction of total sleep time by approximately 21 min

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