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In neurons, it involves the activation of PI3K/Akt signaling pathway, inhibition of GSK-3, reducing tau phosphorylation, promotion of mitochondrial biogenesis, activation of the Bcl-2 family proteins, and inhibiting apoptosis

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137 A randomized, placebo-controlled, crossover trial involving 30 subjects with mild sleep complaints found 14 days of treatment with 7.5 mg crocetin, a compound extracted from saffron, increased the intensity of sleep drive as measured with EEG

This guide makes no such recommendation