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The SURMOUNT trials demonstrated average weight loss of 20 to 25 percent of body weight, numbers that exceeded anything previously seen with pharmaceutical interventions

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Note: see Appendix for an abbreviated summary of strikingly limited head-to-head RCT evidence that exist at the time of this writing Matiegka defines FFM as bone + skeletal muscle + connective tissue + organs + water

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The glucagon activation primarily drives fat burning rather than glucose release in this context

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10.1016/j.jep.2011.08.037 50 PanY.ZhangY.YuanJ.MaX.ZhaoY.LiY.et al (2020)

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