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2023 Jan 9;13(1):2

As peroxisomes lack the enzymes of the citric acid cycle, any acetyl-CoA from the reaction cannot be degraded to CO 2 and H 2 O but rather must be transferred to mitochondria either as acetylcarnitine or acetate for this to occur

++ An ACO that is determined to be inexperienced with performance-based risk Medicare ACO initiatives but is not eligible to enter the BASIC track's glide path may enter either the BASIC track Level E for all performance years of the agreement period, or the ENHANCED track

Market share for biosimilar entrants is limited by prescriber inertia, formulary lag, and payer contract cycles